Therapeutic protein products provide unique and effective treatments for numerous human
diseases and medical conditions. In many cases, these treatments are used chronically to …

An endothelial cell inhibitor was purified from supernatant of an Epstein-Barr virus–immortalized
cell line and identified as fragments of calreticulin. The purified recombinant NH 2 -…

Human Burkitt lymphoma cell lines give rise to progressively growing subcutaneous tumors
in athymic mice. These tumors are induced to regress by inoculation of Epstein–Barr virus-…

The scientific and regulatory issues that are associated with the possible introduction of 'follow-on'
versions of protein drug products are the topic of considerable debate at present. …

Several angiogenesis inhibitors are fragments of larger proteins that are themselves not
active as angiogenesis inhibitors. Vasostatin, the N-terminal domain of calreticulin inclusive of …

Recently we described a full-length cDNA for the human nuclear enzyme poly(ADP-ribose)
polymerase. Here, we report the chromosomal localization and partial map of the human …

The critical question addressed in this paper regards how industry and regulatory agencies
should manage the risk of adverse events to patients posed by product quality attributes for …

TrnH and the intergenic region betweentrnH andpsbA of the chloroplast genomes of alfalfa (Medicago
sativa), Fabaceae, and petunia (Petunia hybrida), Solanaceae, were sequenced …

IL-10 was originally described as an inhibitory factor produced by murine T h 2 lymphocytes
that suppresses IFN- γ production by activated murine T h 1 lymphocytes. In this study, we …

cDNAs encoding poly(ADP-ribose) polymerase from a human hepatoma lambda gt11
cDNA library were isolated by immunological screening. One insert of 1.3 kilobases (kb) …