Adoptive T-cell therapy (ACT) is an emerging paradigm in which T cells are genetically
modified to target cancer-associated antigens and eradicate tumors. However, challenges …

Enterotoxigenic Escherichia coli (ETEC) causes ∼20% of the acute infectious diarrhea (AID)
episodes worldwide, often by producing heat-stable enterotoxins (STs), which are peptides …

High doses of ionizing radiation induce acute damage to epithelial cells of the gastrointestinal
(GI) tract, mediating toxicities restricting the therapeutic efficacy of radiation in cancer and …

Colorectal cancer (CRC) is a major public health concern, ranking among the leading causes
of cancer death in both men and women. Because of this continued burden there is a clear …

Evaluating a particle profile for parenteral drug products is a well-known challenge due to
inevitable variability of results with limited accuracy to actual particle levels present in the …

Long-lived multipotent stem cells (ISCs) at the base of intestinal crypts adjust their phenotypes
to accommodate normal maintenance and post-injury regeneration of the epithelium. …

Compendia methods have historically been used to assess heavy metals in both drug
products and packaging material extracts. However, these methods have been found to be …

A key hurdle to ensuring patient access to cell and gene therapies (CGTs) and continued
growth of the industry is the management of raw materials. The combination of rapid growth, …

Intestinal stem cells (ISCs) are a long-lived, dynamic cell population at the base of intestinal
crypts that adjust their molecular phenotypes as necessary to meet the maintenance and …

Non-suicidal self-injury (NSSI) is a significant issue among adolescents in the United States
affecting 13% to 25% of young adults. In 2012, Arizona saw over 12,000 adolescents in …