Because of its requirement for signaling by multiple cytokines, Janus kinase 3 (JAK3) is an
excellent target for clinical immunosuppression. We report the development of a specific, …

Nerve crush is a commonly used experimental model in the rat; however, a standard method
of inducing this injury has not been defined. This study examined six crush techniques that …

The effect of long‐term denervation on neuromuscular recovery was studied in a rat hind
limb model. The posterior tibial nerve was transected and repaired immediately or after …

Leachables from pharmaceutical container closure systems can present potential safety
risks to patients. Extractables studies may be performed as a risk mitigation activity to identify …

A practical and science-based approach for addressing toxicological concerns related to
leachables and extractables associated with inhalation drug products Packaging and device …

Background. Immunosuppression via Janus kinase (JAK) 3 inhibition affords significant
prolongation of allograft survival. We investigated the effects of an immunosuppressive regimen …

Elemental impurities in drug products can arise from a number of different sources and via a
number of different means, including the active pharmaceutical ingredient, excipients, the …

Like the three editions that preceded it, this new edition targets markets in health care practice
and educational settings. It addresses practicing nurses and nursing students, together …

This study evaluated the effects of a single intraperitoneal injection of N-methyl-N-nitrosourea
(MNU) in citrate buffer (pH 4.5) at a dose of 75 mg/kg in thirty male and thirty female p53+/…

A 100,000-mile fleet test in nine gasoline-powered passenger cars was carried out. The
impact of motor oil phosphorus levels on engine durability, oil degradation, and exhaust …