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OtherCommentary

Enhancement of Cell-based Vaccine Manufacturing Through Process Intensification

William Whitford, Alain Sourabie and Dushyant Varshney
PDA Journal of Pharmaceutical Science and Technology July 2021, pdajpst.2020.012583; DOI: https://doi.org/10.5731/pdajpst.2020.012583
William Whitford
1 DPS Group;
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  • For correspondence: william.whitford@dpsgroupglobal.com
Alain Sourabie
2 Procelys by Lesaffre;
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  • For correspondence: a.sourabie@procelys.lesaffre.com
Dushyant Varshney
3 Kite Pharma
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  • For correspondence: dushamaya@gmail.com
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Abstract

There are many drivers to intensify the manufacturing of vaccines. The emergence of SARS-CoV-2 has only added to them. Since the pandemic began, we are seeing an acceleration of vaccine development and approval, including application of novel prophylactic vaccine modalities. We have also seen an increase in the appreciation and general understanding of what had been a somewhat obscure discipline. Concurrently, there has been great interest in the application of new understandings and technology to the intensification of biopharmaceutical processes in general. The marriage of these developments defines the field of vaccine manufacturing process intensification. Difficulties in its implementation include the many disparate vaccine types− from conjugate to hybrid to nucleic-acid based. Then, there are the respective and developing manufacturing methods, modes, and platforms− from fermentation of transformed bacteria to the bioreactor culture of recombinant animal cells to production of virus-like particles in transgenic plants. Advances are occurring throughout the biomanufacturing arena, from process development (PD) techniques to manufacturing platforms, materials, equipment, and facilities. Bioprocess intensification refers to systems for producing more product per cell, time, volume, footprint, or cost. The need for vaccine manufacturing process intensification is being driven by desires for cost control, process efficiency, and the heightened pressures of pandemic response. We are seeing great interest in the power of such disciplines as synthetic biology, process simplification, continuous bioprocessing, and digital techniques in the optimization of vaccine PD and manufacturing. Other powerful disciplines here include process automation, improved monitoring, optimized culture materials, and facility design. The intent of this short commentary is to provide a brief review, and a few examples of the exciting advances in the equipment, technology and processes supporting this activity.

  • Digital
  • Enhancement
  • Intensification
  • Process
  • Production
  • Vaccine
  • Received November 25, 2020.
  • Accepted June 30, 2021.
  • Copyright © 2021, Parenteral Drug Association

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PDA Journal of Pharmaceutical Science and Technology: 76 (2)
PDA Journal of Pharmaceutical Science and Technology
Vol. 76, Issue 2
March/April 2022
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Enhancement of Cell-based Vaccine Manufacturing Through Process Intensification
William Whitford, Alain Sourabie, Dushyant Varshney
PDA Journal of Pharmaceutical Science and Technology Jul 2021, pdajpst.2020.012583; DOI: 10.5731/pdajpst.2020.012583

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Enhancement of Cell-based Vaccine Manufacturing Through Process Intensification
William Whitford, Alain Sourabie, Dushyant Varshney
PDA Journal of Pharmaceutical Science and Technology Jul 2021, pdajpst.2020.012583; DOI: 10.5731/pdajpst.2020.012583
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Keywords

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  • Enhancement
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  • process
  • production
  • vaccine

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