Abstract
To minimize ocular discomfort while maintaining efficacy, a delivery system for a topical cardioselective β-adrenoceptor antagonist, betaxolol was developed. Betaxolol was formulated at 0.25% concentration in a cationic exchange resin, as a suspension. A polyacrylic acid polymer was added to increase viscosity and to increase residence time in the cul-de-sac. No significant settling was observed throughout a four-week observation period. Thus, resuspension of the formulation by frequent shaking was not required for uniformity. In rabbits, the ocular bioavailability of 0.25% betaxolol suspension was equivalent to that of 0.5% betaxolol solution.
- Received June 27, 1991.
- Accepted November 11, 1991.
- Copyright © Parenteral Drug Association. All rights reserved.
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