RT Journal Article
SR Electronic
T1 An Analysis of Saturated Conditions in Hydrogen Peroxide Decontamination Applications
JF PDA Journal of Pharmaceutical Science and Technology
JO PDA J Pharm Sci Technol
FD Parenteral Drug Association (PDA)
SP pdajpst.2019.010785
DO 10.5731/pdajpst.2019.010785
A1 John Senger
A1 Clement Cheung
YR 2020
UL http://journal.pda.org/content/early/2020/12/21/pdajpst.2019.010785.abstract
AB This article discusses theoretical aspects of saturated vapor-liquid equilibrium for a hydrogen peroxide-water system at temperatures between 16°C and 30°C and humidities between 20% RH to 65% RH, common in pharmaceutical isolator decontamination applications. A discrepancy is pointed out between two competing sets of empirical relations published in the literature that are used to calculate saturated parameters. It is shown how the two published sets can result in four combinations of equations. The four sets of equations are compared to existing published data as well as new data from experiments conducted in this study and it is shown that one set of relations consistently provides the best match to experimental data. This set comes from a hybrid combination of the previously published equations. This has practical implications for hydrogen peroxide sensors that rely on saturated theory for calibration. In addition, new empirical relations aimed at simplifying the calculation of relevant parameters such as hydrogen peroxide concentration, mole fraction of hydrogen peroxide in the condensed liquid, and relative humidity are presented. The concept of relative saturation is discussed and a new procedure for calculating this parameter during a decontamination cycle is presented, incorporating the results from our experiments. Together the updated theoretical framework and simplified empirical relationships can be used to estimate in a simple, direct, and accurate manner where a decontamination cycle is operating in relation to the 100% saturation level, at which point condensation is likely to form in the isolator. This provides a repeatable and objective measure, useful for monitoring and comparing decontamination cycles.