RT Journal Article
SR Electronic
T1 Proceedings of the 2019 Viral Clearance Symposium, Session 6: Virus-Retentive Filtration
JF PDA Journal of Pharmaceutical Science and Technology
JO PDA J Pharm Sci Technol
FD Parenteral Drug Association (PDA)
SP 349
OP 357
DO 10.5731/pdajpst.2021.012682
VO 76
IS 4
A1 Sean O’Donnell
A1 Glen Bolton
YR 2022
UL http://journal.pda.org/content/76/4/349.abstract
AB Manufactures of therapeutic biological products are required to incorporate downstream unit operations that can inactivate or remove potential viral contaminants from the manufacturing process. The viral filtration unit operation is one of the most robust virus removal steps incorporated into downstream manufacturing processes. The primary virus removal mechanism is size exclusion by a network of nanopores in the viral filter membrane. Even though the mechanism of virus removal is size based, there are many operational parameters that can affect virus retention. This article summarizes the current understanding of the operation and validation parameters of this unit operation.