TY - JOUR T1 - Proceedings of the 2019 Viral Clearance Symposium, Session 6: Virus-Retentive Filtration JF - PDA Journal of Pharmaceutical Science and Technology JO - PDA J Pharm Sci Technol SP - 349 LP - 357 DO - 10.5731/pdajpst.2021.012682 VL - 76 IS - 4 AU - Sean O’Donnell AU - Glen Bolton Y1 - 2022/07/01 UR - http://journal.pda.org/content/76/4/349.abstract N2 - Manufactures of therapeutic biological products are required to incorporate downstream unit operations that can inactivate or remove potential viral contaminants from the manufacturing process. The viral filtration unit operation is one of the most robust virus removal steps incorporated into downstream manufacturing processes. The primary virus removal mechanism is size exclusion by a network of nanopores in the viral filter membrane. Even though the mechanism of virus removal is size based, there are many operational parameters that can affect virus retention. This article summarizes the current understanding of the operation and validation parameters of this unit operation. ER -