PT - JOURNAL ARTICLE AU - Liang Fang AU - Marissa Rase TI - Excipient and Packaging Material Impact on Glass and Polymer-Based Prefilled Syringe Functionality AID - 10.5731/pdajpst.2022.012760 DP - 2023 Jan 01 TA - PDA Journal of Pharmaceutical Science and Technology PG - pdajpst.2022.012760 4099 - http://journal.pda.org/content/early/2023/09/15/pdajpst.2022.012760.short 4100 - http://journal.pda.org/content/early/2023/09/15/pdajpst.2022.012760.full AB - Compared to glass prefilled syringes (PFS), cyclic olefin polymer (COP) PFS showed more consistent and predictable extrusion forces when exposed to a variety of excipient combinations (buffers, tonicity agents, and surfactants) at various accelerated storage conditions. Furthermore, COP PFSs also showed significantly less variance in extrusion forces within each individual stroke, which is critical for precision applications. Observed performance differences can be explained by fundamental differences in the stability and homogeneity of the primary packaging materials (i.e., COP vs siliconized glass) and their physicochemical interactions with excipients.