RT Journal Article
SR Electronic
T1 Rethinking Human Factors in Obesity: Development of Simulation and Physical Test Models of Human Soft Tissue to Study Autoinjector Activation Performance
JF PDA Journal of Pharmaceutical Science and Technology
JO PDA J Pharm Sci Technol
FD Parenteral Drug Association (PDA)
SP 530
OP 531
DO 10.5731/pdajpst.2024.012993
VO 78
IS 4
A1 Linvill, Eric
A1 Tsai, Chung
A1 Ravaynia, Paolo
A1 Chang, Chun
A1 Brolin, Karin
A1 Alvarez, Victor
A1 Jonasson, Sofia
YR 2024
UL http://journal.pda.org/content/78/4/530.abstract
AB Activation against a hard surface according to ISO 11608-1 is not always representative of device use on a soft injection site. A softer injection site – which is an anthropometric property found in obese patients – presents a distinct viscoelastic property which can lead to greater autoinjector activation forces that are not captured in standardized activation testing methodology. Soft tissue simulation and physical testing were developed at SHL to advance the development of autoinjectors, allowing for rigorous testing and challenging these in scenarios involving even the softest injection sites.