PT  - JOURNAL ARTICLE
AU  - Butler, L. David
AU  - Haydu, Ernest J.
AU  - Chrair, Suggy
TI  - Steam Sterilization of Rubber Closures in Sealed Nylon Bags
DP  - 1982 May 01
TA  - PDA Journal of Pharmaceutical Science and Technology
PG  - 99--101
VI  - 36
IP  - 3
4099  - http://journal.pda.org/content/36/3/99.short
4100  - http://journal.pda.org/content/36/3/99.full
SO  - PDA J Pharm Sci Technol1982 May 01; 36
AB  - A process has been developed for sterilizing rubber closures in sealed double nylon bags fitted with Nomex breather strips. The sterilization cycle parameters were determined by monitoring heat penetration during autoclaving and correlating the temperature data with biological impact through the use of spore strips and stoppers contaminated with spore suspension. Other variables of importance to the process are the width of the breather strip, the number of stoppers in the bag, and the method of placing the filled bags on pallets for autoclaving.