PT  - JOURNAL ARTICLE
AU  - Neil R. Anderson
AU  - John J. Motzi
TI  - Permeation of Preservative through Rubber Membranes as a Basis for Predicting Loss of Preservative into Rubber Closures
DP  - 1982 Jul 01
TA  - PDA Journal of Pharmaceutical Science and Technology
PG  - 161--167
VI  - 36
IP  - 4
4099  - http://journal.pda.org/content/36/4/161.short
4100  - http://journal.pda.org/content/36/4/161.full
SO  - PDA J Pharm Sci Technol1982 Jul 01; 36
AB  - Loss of preservative due to sorption by rubber closures was investigated. A diffusion cell was constructed and successfully utilized to measure the permeation of methyl paraben through thin sheets of a commercial natural rubber compound. Three mathematical transport models were presented to describe one, two, and three dimensional diffusion of a gas in rubber. Prediction profiles of the sorption of methyl paraben by a commercial natural rubber closure were calculated from the transport models utilizing the values obtained from the membrane permeation studies. Closure sorption tests were performed and the results were compared to the calculated prediction profiles.