PT - JOURNAL ARTICLE AU - W. Douglas Walkling AU - Francis A. Chrzanowski AU - Ronald C. Mamajek AU - Barry J. Fegely AU - Nancy E. Mobley AU - Lucy A. Ulissi TI - Solubilization of Zomepirac DP - 1982 Sep 01 TA - PDA Journal of Pharmaceutical Science and Technology PG - 190--193 VI - 36 IP - 5 4099 - http://journal.pda.org/content/36/5/190.short 4100 - http://journal.pda.org/content/36/5/190.full SO - PDA J Pharm Sci Technol1982 Sep 01; 36 AB - The solubilization of zomepirac, a non-narcotic analgesic, by tromethamine and related bases is described. Solubilization is affected by a micellar mechanism as demonstrated by the surface tension reduction of tromethamine solutions by zomepirac, the solubilization of benzyl alcohol in tromethamine solution by zomepirac and the formation of the characteristic osmotic pressure/concentration relationship for association colloids by equimolar zomepirac:tromethamine solutions.