RT Journal Article
SR Electronic
T1 Solubilization of Zomepirac
JF PDA Journal of Pharmaceutical Science and Technology
JO PDA J Pharm Sci Technol
FD Parenteral Drug Association (PDA)
SP 190
OP 193
VO 36
IS 5
A1 W. Douglas Walkling
A1 Francis A. Chrzanowski
A1 Ronald C. Mamajek
A1 Barry J. Fegely
A1 Nancy E. Mobley
A1 Lucy A. Ulissi
YR 1982
UL http://journal.pda.org/content/36/5/190.abstract
AB The solubilization of zomepirac, a non-narcotic analgesic, by tromethamine and related bases is described. Solubilization is affected by a micellar mechanism as demonstrated by the surface tension reduction of tromethamine solutions by zomepirac, the solubilization of benzyl alcohol in tromethamine solution by zomepirac and the formation of the characteristic osmotic pressure/concentration relationship for association colloids by equimolar zomepirac:tromethamine solutions.