RT Journal Article
SR Electronic
T1 The Targeting of Drugs Parenterally by Use of Microspheres
JF PDA Journal of Pharmaceutical Science and Technology
JO PDA J Pharm Sci Technol
FD Parenteral Drug Association (PDA)
SP 242
OP 248
VO 36
IS 6
A1 Illum, L.
A1 Davis, S. S.
YR 1982
UL http://journal.pda.org/content/36/6/242.abstract
AB The use of microspheres as drug carrier systems is reviewed and discussed and specific details are given of recent work conducted as part of a joint program between the Schools of Pharmacy at Nottingham and Copenhagen. The physicochemical properties that influence the fate and deposition of colloidal particles following parenteral administration include particle size, surface charge, and surface hydropho-bicity. Adsorbed blood components also play a significant role. Drug targeting can be achieved in certain instances, although following intravenous administration, the major site of particle deposition is the liver. A relocation of the particles can be achieved by pharmaceutical formulation (e.g., coating with nonionic surfactants). In vivo experiments using the rabbit demonstrate the important characteristics of a model microsphere controlled release system based on DEAE-cellulose. The use of monoclonal antibodies as a coating agent to increase site specificity is also discussed.