TY - JOUR T1 - Determination of Ethylene Oxide in “12/88” Sterilizing Gas Mixture by Infrared Spectroscopy JF - PDA Journal of Pharmaceutical Science and Technology JO - PDA J Pharm Sci Technol SP - 6 LP - 9 VL - 37 IS - 1 AU - Pat F. Cogswell Y1 - 1983/01/01 UR - http://journal.pda.org/content/37/1/6.abstract N2 - A rapid method of quantitatively determining the ethylene oxide content of the sterilizing gas mixture of 12 wt% ethylene oxide, 88 wt% dichlorodifluoromethane (“12/88”) By infrared(IR)spectroscopy has been developed. The liquified sterilizing gas is sampled as a liquid, vaporized, and collected as a gas. The gas is then brought to a set, constant temperature and pressure and its absorbance read at the maximum near 1291 cm–’.The percent ethylene oxide is then determined using a standard curve. This method requires approximately one-fifth of the time required for the wet chemical method. It also has an advantage over the gas chromatographic method, in that analyst and instrument time is greatly reduced. ER -