PT  - JOURNAL ARTICLE
AU  - Huang, C. R.
AU  - Chao, J. F.
AU  - Huang, J. J.
TI  - Parametric Pumping—A Unique Separation Science
DP  - 1983 Jan 01
TA  - PDA Journal of Pharmaceutical Science and Technology
PG  - 9--12
VI  - 37
IP  - 1
4099  - http://journal.pda.org/content/37/1/9.short
4100  - http://journal.pda.org/content/37/1/9.full
SO  - PDA J Pharm Sci Technol1983 Jan 01; 37
AB  - Parametric pumping is a unique separation or purification process for a mixture of components in a fluid phase. The process includes cyclic steps of fluid passing through an immobile phase and change of an intensive thermodynamic variable. The intensive variable which causes the separation can be temperature, pH, ionic strength, electric field, or affinity. We have studied the model systems such as toluene-aniline-n-heptane, glucose-fructose-water, hemoglobin-albumin, and alkaline phosphatase-other proteins. Results indicate that parametric pumping has the capability to separate or purify biochemicals where other conventional methods might fail. Recently our efforts have concentrated on the application of this unique technique to biochemicals such as proteins and enzymes. Our aim is to serve the pharmaceutical industry with this new separation or purification process. We will be happy to work with any pharmaceutical company to solve a real separation problem in which higher purification is demanded.