RT Journal Article
SR Electronic
T1 Non-Destructive Headspace Gas Analysis in Pharmaceutical Amputes by 5145 A Lasar Raman Spectroscopy
JF PDA Journal of Pharmaceutical Science and Technology
JO PDA J Pharm Sci Technol
FD Parenteral Drug Association (PDA)
SP 127
OP 133
VO 34
IS 2
A1 Bailey, GLEN F.
A1 Moore, Herbert A.
YR 1980
UL http://journal.pda.org/content/34/2/127.abstract
AB A method has been evaluated for non-destructive analysis of the gas headspace in ampuls. We determined with a Raman spectrometer the rotational spectra of the headspace gas in a series of ampuls purged with known O2/N2 mixtures, and the relative rotational scattering coefficients for O2 and N2 at atmospheric pressure. Calculated O2 concentrations were in excellent agreement with the known composition of the purge gases. The method is safe. sensitive, objective. universally applicable. and could be adapted to total-inspection quality control in automatic or semi-automatic industrial settings.