PT  - JOURNAL ARTICLE
AU  - Flora, K. P.
AU  - Rahman, A.
AU  - Cradock, J. C.
TI  - Low Temperature Vacuum Drying: Evaluation of Excipients in injectable Dosage Forms
DP  - 1980 May 01
TA  - PDA Journal of Pharmaceutical Science and Technology
PG  - 192--199
VI  - 34
IP  - 3
4099  - http://journal.pda.org/content/34/3/192.short
4100  - http://journal.pda.org/content/34/3/192.full
SO  - PDA J Pharm Sci Technol1980 May 01; 34
AB  - Low temperature vacuum drying is an alternative to sterile dry filling as a formulation approach for certain ethanol soluble substances that are poorly soluble or unstable in aqueous media. To date this approach has been limited to formulations containing the drug per se. However, several substances appear suitable as excipients including urea, polyethylene glycol 4000, ascorbic acid, methylparaben, and propylparaben. Ascorbic acid appears to increase the stability of bruceantin, a novel plant product that exhibits antitumor activity.