RT Journal Article
SR Electronic
T1 Low Temperature Vacuum Drying: Evaluation of Excipients in injectable Dosage Forms
JF PDA Journal of Pharmaceutical Science and Technology
JO PDA J Pharm Sci Technol
FD Parenteral Drug Association (PDA)
SP 192
OP 199
VO 34
IS 3
A1 Flora, K. P.
A1 Rahman, A.
A1 Cradock, J. C.
YR 1980
UL http://journal.pda.org/content/34/3/192.abstract
AB Low temperature vacuum drying is an alternative to sterile dry filling as a formulation approach for certain ethanol soluble substances that are poorly soluble or unstable in aqueous media. To date this approach has been limited to formulations containing the drug per se. However, several substances appear suitable as excipients including urea, polyethylene glycol 4000, ascorbic acid, methylparaben, and propylparaben. Ascorbic acid appears to increase the stability of bruceantin, a novel plant product that exhibits antitumor activity.