PT  - JOURNAL ARTICLE
AU  - Akers, Michael J.
AU  - Avis, Kenneth E.
AU  - Thompson, Barbara
TI  - Validation Studies of the Fostoria Infrared Tunnel Sterilizer
DP  - 1980 Sep 01
TA  - PDA Journal of Pharmaceutical Science and Technology
PG  - 330--347
VI  - 34
IP  - 5
4099  - http://journal.pda.org/content/34/5/330.short
4100  - http://journal.pda.org/content/34/5/330.full
SO  - PDA J Pharm Sci Technol1980 Sep 01; 34
AB  - Tunnel sterilizers are being applied increasingly for the continuous sterilization and depyrogenation of glass containers used for parenteral medications. They impose validation parameters quite different from batch sterilizers. This study delineates a program and the results obtained in the validation of an infrared tunnel, encompassing thermal consistency and reproducibility, heat penetration of different-sized glass containers, measurement of air and container particulate matter, microbial lethality, and pyrogen destruction measured with the Limulus Amebocyte Lysate test.