PT  - JOURNAL ARTICLE
AU  - Ted Myers
AU  - Suggy Chrai
TI  - Design Considerations for Development of Steam In-Place Sterilization Processes
DP  - 1981 Jan 01
TA  - PDA Journal of Pharmaceutical Science and Technology
PG  - 8--12
VI  - 35
IP  - 1
4099  - http://journal.pda.org/content/35/1/8.short
4100  - http://journal.pda.org/content/35/1/8.full
SO  - PDA J Pharm Sci Technol1981 Jan 01; 35
AB  - A process is described for the steam in-place sterilization of a closed system sterile holding tank assembled with product and vent filtration equipment. This process permits complete non-aseptic assembly of the system, thereby eliminating aseptic manipulations that may result in equipment contamination. The development of this system involved a detailed evaluation of equipment design and limitations on process operation. Additional studies were performed examining suitable methods for steam in-place sterilization of hydrophilic and hydrophobic filters.