RT Journal Article
SR Electronic
T1 Determination of the Vacuum Outgassing Properties of Elastic Closures by Mass Spectrometry
JF PDA Journal of Pharmaceutical Science and Technology
JO PDA J Pharm Sci Technol
FD Parenteral Drug Association (PDA)
SP 100
OP 105
VO 35
IS 3
A1 Leebron, Kathryn S.
A1 Jennings, Thomas A.
YR 1981
UL http://journal.pda.org/content/35/3/100.abstract
AB This paper reports the results of a mass spectrometric study of the outgassing properties of elastic closures. The closures examined were those typically used in the lyophilization process. The detection system was an ion differentially pumped quadrupole mass spectrometer. Outgassing studies of the closures were conducted in a glass vacuum system and a 24-ft2 vacuum freeze dryer. Examination of the mass spectra of vapors from the glass system is discussed. Results of studies conducted in a 24-ft2 vacuum freeze dryer indicate the presence of closure outgassing vapors at various shelf temperatures.