RT Journal Article
SR Electronic
T1 The Application of Gas Chromatography/Mass Spectrometry to the Analysis of Pharmaceutical Packaging Materials
JF PDA Journal of Pharmaceutical Science and Technology
JO PDA J Pharm Sci Technol
FD Parenteral Drug Association (PDA)
SP 152
OP 161
VO 35
IS 4
A1 Kiang, Patty H.
YR 1981
UL http://journal.pda.org/content/35/4/152.abstract
AB This paper discusses the applications ofGC/MS (gas chromatography/mass spectrometry)to the analysis of elastomeric pharmaceutical packaging materials. Basic GC/MS techniques and theory are described. The use of the GC/MS for the analysis of elastomeric materials can be performed by: (a) direct solid probe insertion mass spectrometry, (b) conventional GC/MS, and (c) pyrolysis GC/MS. GC/MS is a powerful tool when used for the analysis of trace quantities of materials, particularly pharmaceuticals and pharmaceutical packaging materials. This application invoiced the establishment of sampling techniques, building a “User’s Library” using known standards, and the analysis of actual samples. Case studies of actual analyses are presented to illustrate the application of GC/MS to typical, pharmaceutical packaging problems.