RT Journal Article
SR Electronic
T1 Human Interferon—Properties, Clinical Application, and Production
JF PDA Journal of Pharmaceutical Science and Technology
JO PDA J Pharm Sci Technol
FD Parenteral Drug Association (PDA)
SP 223
OP 226
VO 35
IS 5
A1 Horowitz, Bernard
YR 1981
UL http://journal.pda.org/content/35/5/223.abstract
AB Interferon synthesis is stimulated by a variety of factors including exposure to virus, antigen, or antibody and various mitogens. Three classes of interferon have been described and multiple subtypes identified. The use of interferon in clinical trials for the treatment of cancer and viral infections has been limited by the relatively low quantities of interferon available. Nonetheless, preliminary evidence suggests that human interferon has potent pharmacologic activity against at least some forms of cancer and viral infection. Extended clinical evaluation will be made possible by newly developed production processes, including the application of large scale biosynthesis and separation methodologies to interferon produced by human cells and the incorporation of human genes for interferons into simple, unicellular organisms.