PT  - JOURNAL ARTICLE
AU  - Lukaszewicz, Raymond C.
AU  - Korin, Amos
AU  - Hauk, Dale
AU  - Chrai, Suggy
TI  - Functionality and Economics of Tangential Flow Microfiltration
DP  - 1981 Sep 01
TA  - PDA Journal of Pharmaceutical Science and Technology
PG  - 231--236
VI  - 35
IP  - 5
4099  - http://journal.pda.org/content/35/5/231.short
4100  - http://journal.pda.org/content/35/5/231.full
SO  - PDA J Pharm Sci Technol1981 Sep 01; 35
AB  - Filtration of test solutions through a 0.2 μm-rated pore size pleated membrane filter cartridge, designed for operation in a tangential (crossflow) mode, shows that throughputs with such systems are many fold greater than with comparable uni-directional (dead end) cartridge filters. Although the crossflow cartridge is more expensive than the traditional cartridge filter, cost per liter of filtrate is reduced by at least 50% because of the improvement in throughput. An example of biologic processing illustrates the unusual flexibility of the crossflow system. This study compares conventional uni-directional filtration with the practice and economics of a new tangential flow (crossflow) microporous filter cartridge system. Studies with biological solutions, water, and parenteral fluids invariably showed that tangential flow filtrate throughputs were many fold greater than for unidirectional microporous filtration and that significant economic justification exists for the use of tangential flow filtration in many pharmaceutical applications.