RT Journal Article
SR Electronic
T1 Glass and Rubber Closure Effects on the pH of Water l.A Preliminary Investigation
JF PDA Journal of Pharmaceutical Science and Technology
JO PDA J Pharm Sci Technol
FD Parenteral Drug Association (PDA)
SP 11
OP 17
VO 38
IS 1
A1 Preston, Wendy A.
A1 Neil R., Anderson
YR 1984
UL http://journal.pda.org/content/38/1/11.abstract
AB Water packaged in three different types of 10-ml serum vials and sealed with a butyl rubber closure was exposed to extended steam autoclave cycles and high temperature storage. The results of the tests show a reduction in pH values and an increase in a UV absorbance that is dependent on time and temperature. The final pH of the water after storage may be the result of an interaction between glass and rubber extractives.