PT  - JOURNAL ARTICLE
AU  - Wang, Y. J.
AU  - Leesman, G. D.
AU  - Dahl, T. C.
AU  - Monkhouse, D. C.
TI  - Optimization of Autoclave Cycles and Selection of Formulation for Parenteral Products, Part I: Identification of Autoclave Conditions by a Nonisothermal Approach
DP  - 1984 Mar 01
TA  - PDA Journal of Pharmaceutical Science and Technology
PG  - 68--72
VI  - 38
IP  - 2
4099  - http://journal.pda.org/content/38/2/68.short
4100  - http://journal.pda.org/content/38/2/68.full
SO  - PDA J Pharm Sci Technol1984 Mar 01; 38
AB  - This report describes a method to determine optimal autoclave conditions, i.e., exposure time and temperature. Using chemical degradation and spore kill data from each complete cycle, a nonisothermal run, one can determine first-order kinetic parameters from a nonlinear least squares program. By employing these kinetic parameters, contour curves for exposure time and temperature can be constructed to represent the conditions that will produce a predetermined spore kill and degradation. The optimized conditions for autoclave sterilization are to be found in the area enclosed by these contour curves.