PT  - JOURNAL ARTICLE
AU  - Fort, Farrel L.
AU  - Heyman, Irwin A.
AU  - Kesterson, James W.
TI  - Hemolysis Study of Aqueous Polyethylene Glycol 400, Propylene Glycol and Ethanol Combinations In Vivo and In Vitro
DP  - 1984 Mar 01
TA  - PDA Journal of Pharmaceutical Science and Technology
PG  - 82--87
VI  - 38
IP  - 2
4099  - http://journal.pda.org/content/38/2/82.short
4100  - http://journal.pda.org/content/38/2/82.full
SO  - PDA J Pharm Sci Technol1984 Mar 01; 38
AB  - Propylene glycohethanohwater (5:1:4) given intravenously for 2 weeks to rats and dogs resulted in hematuria and hematologic changes consistent with intravascular hemolysis. Several combinations of propylene glycol, polyethylene glycol 400, ethanol, saline and/or water were then studied for hemolytic activity both in vivo in rats after intravenous administration and in vitro. Solutions containing propylene glycol:ethanol:saline (1:3:6), ethano:lsaline (3:7), and polyethylene glycol 400:ethanol:water (3:2:5) were found to cause less hemolysis in vivo than the other solutions tested. Polyethylene glycol 400:ethanol:water (3:2:5) was chosen for further evaluation and when given intravenously to dogs for 1 week or rats for 2 weeks, this solution caused no adverse hematologic effects.