RT Journal Article
SR Electronic
T1 Hemolysis Study of Aqueous Polyethylene Glycol 400, Propylene Glycol and Ethanol Combinations In Vivo and In Vitro
JF PDA Journal of Pharmaceutical Science and Technology
JO PDA J Pharm Sci Technol
FD Parenteral Drug Association (PDA)
SP 82
OP 87
VO 38
IS 2
A1 Fort, Farrel L.
A1 Heyman, Irwin A.
A1 Kesterson, James W.
YR 1984
UL http://journal.pda.org/content/38/2/82.abstract
AB Propylene glycohethanohwater (5:1:4) given intravenously for 2 weeks to rats and dogs resulted in hematuria and hematologic changes consistent with intravascular hemolysis. Several combinations of propylene glycol, polyethylene glycol 400, ethanol, saline and/or water were then studied for hemolytic activity both in vivo in rats after intravenous administration and in vitro. Solutions containing propylene glycol:ethanol:saline (1:3:6), ethano:lsaline (3:7), and polyethylene glycol 400:ethanol:water (3:2:5) were found to cause less hemolysis in vivo than the other solutions tested. Polyethylene glycol 400:ethanol:water (3:2:5) was chosen for further evaluation and when given intravenously to dogs for 1 week or rats for 2 weeks, this solution caused no adverse hematologic effects.