PT  - JOURNAL ARTICLE
AU  - Danielson, James W.
AU  - Oxborrow, Gordon S.
AU  - Placencia, Ana M.
TI  - Quantitative Determination of Chemicals Leached from Rubbert Stoppers into Parenteral Solutions
DP  - 1984 May 01
TA  - PDA Journal of Pharmaceutical Science and Technology
PG  - 90--93
VI  - 38
IP  - 3
4099  - http://journal.pda.org/content/38/3/90.short
4100  - http://journal.pda.org/content/38/3/90.full
SO  - PDA J Pharm Sci Technol1984 May 01; 38
AB  - Amounts of some chemical compounds leached from rubber stoppers into large volume parenteral solutions have been determined using gas chromatography. The results, given in micrograms per bottle, show that there are differences in the quantities of stopper components in products of the same lot number, in various products, and in different bottle sizes. The quantitative determination of identified components leached from rubber stoppers provides a means for evaluating the health risks of the extractables.