PT  - JOURNAL ARTICLE
AU  - Deyoung, Joyce L.
AU  - Lien, Eric L.
TI  - A Long-Acting Injectable Dosage Form for a Somatastatin Analog
DP  - 1984 Nov 01
TA  - PDA Journal of Pharmaceutical Science and Technology
PG  - 234--236
VI  - 38
IP  - 6
4099  - http://journal.pda.org/content/38/6/234.short
4100  - http://journal.pda.org/content/38/6/234.full
SO  - PDA J Pharm Sci Technol1984 Nov 01; 38
AB  - In an attempt to prolong the activity of Wy-41,747, a somatostatin analog that has been shown to improve diabetic control in type I human diabetics, the peptide was adsorbed on zinc phosphate. A flocculated suspension was produced that extended the growth hormone suppressing effects of Wy-4l, 747 in rats to at least 17 hr, compared to 2 hr when the peptide is administered dissolved in saline. A suspension prepared using somatostatin in place of Wy-41,747 was not flocculated and gave no prolongation of activity, suggesting that no adsorption occurred. The presence of histidine residues in Wy-41,747 that are not present in somatostatin is postulated to be the reason for the success of the formulation.