@article {Abendroth112, author = {R. Paul Abendroth}, title = {Development of A U.S.P. Type I Glass for the Pharmaceutical Industry}, volume = {39}, number = {3}, pages = {112--114}, year = {1985}, publisher = {Parenteral Drug Association (PDA)}, abstract = {Impetus supplied by the pharmaceutical industry prompted the Kimble Division of Owens-Illinois Inc. to investigate the production of barium-free N-51 A borosilicate glass that could be used to package drugs sensitive to the presence of barium. Kimble initiated an investigation to determine the effect of barium removal on glass properties that dealt with the melting characteristics, and physical and chemical properties of a barium-free N-51 A. The physical properties were essentially unchanged with the exception of the density, which was lowered. Extensive manufacturing trials showed that this glass could be formed into containers under the same conditions as the barium containing composition. The chemical durability of the barium-free composition was evaluated using the containers made during the manufacturing trials. The USP Water Attack Test and Powdered Glass Test were used, and individual extractable glass constituents were determined. No significant difference was found between the barium-containing and barium-free compositions. except that barium was absent in extracts from the barium-free glass. It was concluded that a glass similar to N-51A but essentially free of barium oxide could be produced which would meet all requirements of a USP Type J glass and serve the needs of the pharmaceutical industry.}, issn = {0006-3363}, URL = {https://journal.pda.org/content/39/3/112}, eprint = {https://journal.pda.org/content/39/3/112.full.pdf}, journal = {PDA Journal of Pharmaceutical Science and Technology} }