PT  - JOURNAL ARTICLE
AU  - Gupta, V. Das,
AU  - Stewart, Kenneth R.
TI  - Chemical Stabilities of Hydrocortisone Sodium Succinate and Several Antibiotics When Mixed with Metronidazole Injection for Intravenous Infusion
DP  - 1985 May 01
TA  - PDA Journal of Pharmaceutical Science and Technology
PG  - 145--149
VI  - 39
IP  - 3
4099  - http://journal.pda.org/content/39/3/145.short
4100  - http://journal.pda.org/content/39/3/145.full
SO  - PDA J Pharm Sci Technol1985 May 01; 39
AB  - The chemical stabilities of 7 antibiotics, ampicillin. carbenicillin. cefazolin. cefoxitin, cephalothin. moxalactam. and penicillin G and hydrocortisone sodium succinate when mixed with metronidazole injection have been studied using stability-indicating high-performance liquid chromatography methods. After 3 days of storage at 25° and 12 days at 5°. metronidazole in all solutions was determined to be stable. Hydrocortisone sodium succinate solution did not decompose significantly during 7 days at 25° and 12 days at 5°. Three antibiotics, carbenicillin. cefazolin, and penicillin G were stable for 3 days at 25° (loss in potency less than 10%); and cefoxitin and moxalactam for only 2 days. Ampicillin was stable only for one day at 25° and cephalothin lost more than 10% of the potency in one day. All the antibiotic solutions in metronidazole injection were stable for 12 days at 5°.