RT Journal Article
SR Electronic
T1 Chemical Stabilities of Hydrocortisone Sodium Succinate and Several Antibiotics When Mixed with Metronidazole Injection for Intravenous Infusion
JF PDA Journal of Pharmaceutical Science and Technology
JO PDA J Pharm Sci Technol
FD Parenteral Drug Association (PDA)
SP 145
OP 149
VO 39
IS 3
A1 Gupta, V. Das,
A1 Stewart, Kenneth R.
YR 1985
UL http://journal.pda.org/content/39/3/145.abstract
AB The chemical stabilities of 7 antibiotics, ampicillin. carbenicillin. cefazolin. cefoxitin, cephalothin. moxalactam. and penicillin G and hydrocortisone sodium succinate when mixed with metronidazole injection have been studied using stability-indicating high-performance liquid chromatography methods. After 3 days of storage at 25° and 12 days at 5°. metronidazole in all solutions was determined to be stable. Hydrocortisone sodium succinate solution did not decompose significantly during 7 days at 25° and 12 days at 5°. Three antibiotics, carbenicillin. cefazolin, and penicillin G were stable for 3 days at 25° (loss in potency less than 10%); and cefoxitin and moxalactam for only 2 days. Ampicillin was stable only for one day at 25° and cephalothin lost more than 10% of the potency in one day. All the antibiotic solutions in metronidazole injection were stable for 12 days at 5°.