RT Journal Article
SR Electronic
T1 Stability of Anthracycline Antitumour Agents in Infusion Fluids
JF PDA Journal of Pharmaceutical Science and Technology
JO PDA J Pharm Sci Technol
FD Parenteral Drug Association (PDA)
SP 220
OP 222
VO 39
IS 6
A1 J. H. Beijnen
A1 H. Rosing
A1 Ph.A.de Vries
A1 W. J. M. Underberg
YR 1985
UL http://journal.pda.org/content/39/6/220.abstract
AB The chemical stability of six anthracycline cytostatics has been studied in four different, commonly used, infusion fluids. Stability was determined with the use of high performance liquid chromatography. All compounds tested appeared to be stable in 5% dextrose and 3.3% dextrose-0.3% sodium chloride solutions, during a 28 days’ incubation period at 25°C in the dark. When doxorubicin and its 4′-cogeners are stored in Lactated Ringer’s or 0.9% sodium chloride injection considerable degradation occurs. t90 values are presented. Degradation products could be traced by means of thin layer chromatography. Daunorubicin and 4-demethoxy-daunorubicin are apparently stable in Lactated Ringer’s and 0.9% sodium chloride injection.