PT  - JOURNAL ARTICLE
AU  - Ludwig, John D.
AU  - Avis, Kenneth E.
TI  - Validation of a Heating Cell for Precisely Controlled Studies on the Thermal Destruction of Endotoxin in Glass
DP  - 1988 Jan 01
TA  - PDA Journal of Pharmaceutical Science and Technology
PG  - 9--14
VI  - 42
IP  - 1
4099  - http://journal.pda.org/content/42/1/9.short
4100  - http://journal.pda.org/content/42/1/9.full
SO  - PDA J Pharm Sci Technol1988 Jan 01; 42
AB  - A unique heating cell designed to provide precise control of heat input to samples of Escherichia coli endotoxin in Type I glass capillary tubes is described. The thermal properties of the heating cell were studied. Methodology to charge the capillary tubes with endotoxin and recover the endotoxin for assay were developed. Initial endotoxin destruction data at 170 °C show a 5 log reduction in the amount of endotoxin in approximately 1200 minutes.