RT Journal Article
SR Electronic
T1 Residual Seal Force Measurement of Parenteral Vials. II. Elastomer Evaluation
JF PDA Journal of Pharmaceutical Science and Technology
JO PDA J Pharm Sci Technol
FD Parenteral Drug Association (PDA)
SP 57
OP 61
VO 42
IS 2
A1 Morton, Dana K.
A1 Lordi, Nicholas G.
YR 1988
UL http://journal.pda.org/content/42/2/57.abstract
AB The Instron method of residual seal force measurement is used to study the effects of various closure, time, and processing variables on the residual seal force of parenteral vials. Control vials machined from aluminum with flat, 20-mm serum finishes are used to eliminate inaccuracies inherently caused by glass vial finish variations. The Instron residual seal force is demonstrated to be dependent on closure variables of elastomer formulation, formulation batch, and certain types of inert polymeric coatings. Using halobutyl closures, the seal force is shown to decay with time post sealing and as a result of "terminal" autoclaving