PT  - JOURNAL ARTICLE
AU  - N. S. Kishnani
AU  - G. C Visor
TI  - A Stability and Compatibility Evaluation of a Novel Calcium Entry Blocker in Admixture Preparations
DP  - 1988 Mar 01
TA  - PDA Journal of Pharmaceutical Science and Technology
PG  - 68--71
VI  - 42
IP  - 2
4099  - http://journal.pda.org/content/42/2/68.short
4100  - http://journal.pda.org/content/42/2/68.full
SO  - PDA J Pharm Sci Technol1988 Mar 01; 42
AB  - The chemical and physical stability of a novel calcium entry blocker RS-93007,3-[4-cyano-4-(3,4-di-methoxyphenyl)-5-methylhex-l-yl]-I,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-isoquinoline hydrochloride was evaluated in dextrose and saline admixture preparations. These studies utilized HPLC with electrochemical detection to monitor the drug’s stability and diastereomeric ratio upon storage and delivery in potentially adsorptive infusion materials and devices. Results of these studies indicate no adsorptive losses, incompatibility, or changes in diastereomer ratio occur after dilution of the drug in PVC-based infusion systems. The utility of partitioning studies as a predictive tool for adsorptive losses of drug to plastic infusion containers is discussed.