PT  - JOURNAL ARTICLE
AU  - Olson, W. P.
AU  - Faith, M. R.
TI  - Human Serum Albumin as a Cosolvent for Parenteral Drugs
DP  - 1988 May 01
TA  - PDA Journal of Pharmaceutical Science and Technology
PG  - 82--85
VI  - 42
IP  - 3
4099  - http://journal.pda.org/content/42/3/82.short
4100  - http://journal.pda.org/content/42/3/82.full
SO  - PDA J Pharm Sci Technol1988 May 01; 42
AB  - Diazepam, solubilized in human serum albumin and delivered i.p. to mice, neutralized seizures induced with Metrazole in a mouse epilepsy model. Diazepam-free albumin, injected immediately after the Metrazole, also reduced seizures; albumin binds Metrazole. Heat-denatured rabbit albumin failed to elicit precipitating antibodies in the rabbit. Albumin is a suitable cosolvent for some water-insoluble drugs but probably is not cost-effective.