RT Journal Article
SR Electronic
T1 Human Serum Albumin as a Cosolvent for Parenteral Drugs
JF PDA Journal of Pharmaceutical Science and Technology
JO PDA J Pharm Sci Technol
FD Parenteral Drug Association (PDA)
SP 82
OP 85
VO 42
IS 3
A1 Olson, W. P.
A1 Faith, M. R.
YR 1988
UL http://journal.pda.org/content/42/3/82.abstract
AB Diazepam, solubilized in human serum albumin and delivered i.p. to mice, neutralized seizures induced with Metrazole in a mouse epilepsy model. Diazepam-free albumin, injected immediately after the Metrazole, also reduced seizures; albumin binds Metrazole. Heat-denatured rabbit albumin failed to elicit precipitating antibodies in the rabbit. Albumin is a suitable cosolvent for some water-insoluble drugs but probably is not cost-effective.