RT Journal Article
SR Electronic
T1 A Study of the Solubility of Amphotericin B in Nonaqueous Solvent Systems
JF PDA Journal of Pharmaceutical Science and Technology
JO PDA J Pharm Sci Technol
FD Parenteral Drug Association (PDA)
SP 97
OP 102
VO 42
IS 3
A1 Rajagopalan, Natarajan
A1 Dicken, C. Michael
A1 Ravin, Louis, J.
A1 Sternson, Larry A.
YR 1988
UL http://journal.pda.org/content/42/3/97.abstract
AB The solubility of amphotericin B, a potent antifungal antibiotic, was determined in solvents deemed acceptable for use in i.v. formulations. A total of eighteen solvent mixtures (binary and ternary) were used in the solubility screen. The collected solubility data indicate that only two solvent systems, PEG 400/propylene glycol (50/50) and N,N-dimethylacetamide yielded an amphotericin B solubility > I mg/mL. The solubility of amphotericin B in the aprotic solvent N,N-dimethylacetamide was observed to dramatically increase from 7.6 to 152.4 mg/mL in the presence of added 6.0% w/v sodium deoxycholate. Surface tension and conductivity measurements indicate that the mechanism for this dramatic increase in the solubility of amphotericin B in the presence of added sodium deoxycholate is not micellar. Preliminary data suggest that a plausible explanation for the solubility enhancement in the presence of added sodium deoxycholate involves the formation of ion pairs.