PT  - JOURNAL ARTICLE
AU  - Slater, G. J.
AU  - Johnston, D.
TI  - Microbiological Environmental Monitoring during Sterile Product Manufacture: Adaptation of Methods for a Research Facility
DP  - 1988 Jul 01
TA  - PDA Journal of Pharmaceutical Science and Technology
PG  - 111--113
VI  - 42
IP  - 4
4099  - http://journal.pda.org/content/42/4/111.short
4100  - http://journal.pda.org/content/42/4/111.full
SO  - PDA J Pharm Sci Technol1988 Jul 01; 42
AB  - The environmental monitoring procedures applied during sterile product manufacture were optimized by use of multiple settle plates, larger diameter settle plates (14 cm), and extended exposure times in order to detect I cfu/m3 air. Due to the small batch size and short working time within the Class I area the exposure time could not be extended sufficiently to represent I cfu/m3 by 2 or more colonies per plate. The maximum exposure time that could be employed was 4 hours and, therefore, I cfu/m3 was represented by a total of 4 colonies on 4 × 14-cm settle plates.