RT Journal Article
SR Electronic
T1 Low Temperature Solubility of Antibiotics: Oxacillin Sodium
JF PDA Journal of Pharmaceutical Science and Technology
JO PDA J Pharm Sci Technol
FD Parenteral Drug Association (PDA)
SP 177
OP 180
VO 42
IS 6
A1 Mishra, Dinesh S.
A1 Patel, Suresh D.
A1 Marsht, DAVID
A1 Yalkowsk, Samuel H.
YR 1988
UL http://journal.pda.org/content/42/6/177.abstract
AB The solubility of oxacillin sodium in methanol-water mixtures has been determined at various temperatures ranging from +21 to –26°C. The data has been fitted to a log-linear relationship. The heat of solution is determined using the van’t Hoff equation and was found to be nearly constant at 1.2 Kcal/mole. There appears to be no dependency of the slope of the log Sm vs. fraction cosolvent plot upon temperature. DSC data indicate that there is an eutectic freezing point for oxacillin solutions between –12 and–13°C. The above data suggest that premixed intravenous solutions of oxacillin will be considerably more stable when stored below, rather than above, the eutectic point.