RT Journal Article
SR Electronic
T1 Stability of Vinca Alkaloid Anticancer Drugs in Three Commonly Used Infusion Fluids
JF PDA Journal of Pharmaceutical Science and Technology
JO PDA J Pharm Sci Technol
FD Parenteral Drug Association (PDA)
SP 84
OP 87
VO 43
IS 2
A1 J. H. Beijnen
A1 D. E. M. M. Vendrig
A1 W. J. M. Underberg
YR 1989
UL http://journal.pda.org/content/43/2/84.abstract
AB The chemical stabilities of the vinca alkaloid anticancer drugs vinblastine, vincristine, and vindesine have been studied in three commonly used infusion fluids at 4 and 25°C. The infusion fluids were: 0.9% sodium chloride, 5% dextrose, and Ringer’s Lactate injection. Stability has been measured by using a stability-indicating high performance liquid chromatographic assay with ultraviolet detection. At 4°C no significant degradation of the vinca alkaloids occurred within a storage period of three weeks. The stability tests at 25°C also revealed that vinblastine, vincristine, and vindesine are stable (>95% remained) when stored for three weeks at this temperature in 5% dextrose. 0.9% sodium chloride, or Ringer’s Lactate infusion fluids.