PT - JOURNAL ARTICLE AU - Dana K. Morton AU - Nicholas G. Lordi AU - Thomas J. Ambrosio TI - Quantitative and Mechanistic Measurements of Parenteral Vial Container/Closure Integrity. Leakage Quantitation DP - 1989 Mar 01 TA - PDA Journal of Pharmaceutical Science and Technology PG - 88--97 VI - 43 IP - 2 4099 - http://journal.pda.org/content/43/2/88.short 4100 - http://journal.pda.org/content/43/2/88.full SO - PDA J Pharm Sci Technol1989 Mar 01; 43 AB - Leakage across the parenteral vial/closure seal interface is quantitatively measured in terms of mass of gas per unit time using a differential pressure method of leakage measurement. With this test system, uncoated, PurcoatĀ® coated, and film coated closures are compared for their ability to seal nondefective and defective vial surfaces. Correlations are made between closure sealing performance and rubber viscoelasticity, closure coating material type and thickness, and crimped vial residual seal force.