RT Journal Article
SR Electronic
T1 Aluminum in Parenteral Products: Analysis, Reduction, and Implications for Pediatric TPN
JF PDA Journal of Pharmaceutical Science and Technology
JO PDA J Pharm Sci Technol
FD Parenteral Drug Association (PDA)
SP 132
OP 139
VO 43
IS 3
A1 Barrett E. Rabinow
A1 Scott Ericson
A1 Tim Shelborne
YR 1989
UL http://journal.pda.org/content/43/3/132.abstract
AB Performance and cost of the best available analytical methodology for the measurement of aluminum in parenteral products are presented. Typical levels of aluminum in representative solutions are summarized. A methodical approach to the minimization of aluminum contamination in the manufacturing process is considered in light of aqueous aluminum chemical considerations. Results of long-term clinical follow-up studies of infants maintained on currently manufactured TPN solutions indicate no adverse pathology arising from aluminum.