PT  - JOURNAL ARTICLE
AU  - Brewster, Marcus E.
AU  - Estes, Kerry S.
AU  - Bodor, Nicholas
TI  - Development of a Non-Surfactant Formulation for Alfaxalone Through the Use of Chemically-Modified Cyclodextrins
DP  - 1989 Nov 01
TA  - PDA Journal of Pharmaceutical Science and Technology
PG  - 262--265
VI  - 43
IP  - 6
4099  - http://journal.pda.org/content/43/6/262.short
4100  - http://journal.pda.org/content/43/6/262.full
SO  - PDA J Pharm Sci Technol1989 Nov 01; 43
AB  - The poor water solubility of alfaxalone (5 μg/mL). a useful steroid anesthetic agent, was dramatically increased via complexation with a series of four cyclodextrins. The most effective agent was 2-hydroxypropyl-β-cyclodextrin (2HPCD) which solubilized alfaxalone in a linear manner as a function of concentration. At a 2HPCD concentration of 50% w/v, approximately 80 mg/mL of alfaxalone was dissolved indicating an increase in aqueous solubility of over four orders of magnitude. The cyclodextrin solution was stable to autoclaving and could be conveniently lyophilized to yield a solid product.