RT Journal Article
SR Electronic
T1 Development of a Non-Surfactant Formulation for Alfaxalone Through the Use of Chemically-Modified Cyclodextrins
JF PDA Journal of Pharmaceutical Science and Technology
JO PDA J Pharm Sci Technol
FD Parenteral Drug Association (PDA)
SP 262
OP 265
VO 43
IS 6
A1 Brewster, Marcus E.
A1 Estes, Kerry S.
A1 Bodor, Nicholas
YR 1989
UL http://journal.pda.org/content/43/6/262.abstract
AB The poor water solubility of alfaxalone (5 μg/mL). a useful steroid anesthetic agent, was dramatically increased via complexation with a series of four cyclodextrins. The most effective agent was 2-hydroxypropyl-β-cyclodextrin (2HPCD) which solubilized alfaxalone in a linear manner as a function of concentration. At a 2HPCD concentration of 50% w/v, approximately 80 mg/mL of alfaxalone was dissolved indicating an increase in aqueous solubility of over four orders of magnitude. The cyclodextrin solution was stable to autoclaving and could be conveniently lyophilized to yield a solid product.