RT Journal Article
SR Electronic
T1 Ozone: Pharmaceutical Sterilant of the Future?
JF PDA Journal of Pharmaceutical Science and Technology
JO PDA J Pharm Sci Technol
FD Parenteral Drug Association (PDA)
SP 256
OP 261
VO 39
IS 6
A1 Gurley, Bill
YR 1985
UL http://journal.pda.org/content/39/6/256.abstract
AB Ozone owes its excellent bactericidal, virucidal, and sporicidal activities in water to its powerful oxidizing properties. The most important factor in microbial kill is the quantity of ozone transferred into the water, although ozone sterilization efficiency is also dependent on the type of microorganism, concentration of dissolved organics, temperature, and pH. Recent modifications in ozonator design and water/ozone contact mechanisms have made ozonation a cost competitive sterilization technique for the pharmaceutical industry particularly in the area of parenterals. Three applications that have received the most attention are terminal sterilization of aqueous drug formulations, sterilization of glass and plastic containers, and preparation of sterile process water.